NFL Lines – 2019 Week 5
| Date & Time | Favorite | Line | Underdog | Total |
| 10/6 1:00 ET | Baltimore | -3.5 | At Pittsburgh | 44.5 |
| 10/6 1:00 ET | Chicago | -5.5 | Oakland (London) |
40.5 |
| 10/6 1:00 ET | At Cincinnati | -3 | Arizona | 47.5 |
| 10/6 1:00 ET | At Carolina | -3.5 | Jacksonville | 41 |
| 10/6 1:00 ET | Minnesota | -5 | At NY Giants | 43.5 |
| 10/6 1:00 ET | New England | -15.5 | At Washington | 42.5 |
| 10/6 1:00 ET | At Philadelphia | -14.5 | NY Jets | 44 |
| 10/6 1:00 ET | At New Orleans | -3 | Tampa Bay | 47 |
| 10/6 1:00 ET | At Houston | -4.5 | Atlanta | 49 |
| 10/6 1:00 ET | At Tennessee | -3 | Buffalo | 38.5 |
| 10/6 4:05 ET | At LA Chargers | -6.5 | Denver | 44.5 |
| 10/6 4:25 ET | At Dallas | -3.5 | Green Bay | 47 |
| 10/6 8:20 ET | At Kansas City | -11 | Indianapolis | 56.5 |
Monday Night
| 10/7 8:15 ET | At San Francisco | -4 | Cleveland | 46.5 |
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